Ubiquitination is absolutely required for the degradation of hypoxia-inducible factor - 1 alpha protein in hypoxic conditions

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

G L Wang, Bing‐Hua Jiang, E A Rue et al. · Proceedings of the National Academy of Sciences · 1995 · 6.2K citations

Life Sciences, Cell Biology, Molecular Biology +17

Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

James Brugarolas, Kui Lei, Rebecca L. Hurley et al. · Genes & Development · 2004 · 1.4K citations · Full text

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Regulation of Hypoxia-Inducible Factor 1α Expression and Function by the Mammalian Target of Rapamycin

Christine C. Hudson, Mei Liu, Gary G. Chiang et al. · Molecular and Cellular Biology · 2002 · 1.2K citations · Full text

Medicine, Oncology, Pharmacology +15

Components of ubiquitin-protein ligase system. Resolution, affinity purification, and role in protein breakdown.

Avram Hershko, H Heller, Sarah Elias et al. · Journal of Biological Chemistry · 1983 · 1.1K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14

Loss of <i>PTEN</i> facilitates HIF-1-mediated gene expression

Wayne Zundel, Cornelia Schindler, Daphne A. Haas‐Kogan et al. · Genes & Development · 2000 · 833 citations · Full text

Medicine, Cancer Biology, Oncology +17