A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain

Bart De Strooper, Wim Annaert, Philippe Cupers, +9

Nature

Protein SecretionProtein FunctionSignal TransductionImmunologyNotch Intracellular Domain +6

Dynasore, a Cell-Permeable Inhibitor of Dynamin

Eric Macia, Marcelo Ehrlich, Ramiro Massol, +3

Developmental Cell

BiochemistryMedicineMechanism Of ActionCell-permeable InhibitorMembrane Biology +6

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

Eric H. Schroeter, Jeffrey A. Kisslinger, Raphael Kopan

Nature

Signal TransductionSignaling PathwayCell InteractionNotch-1 SignallingCellular Biochemistry +4

Signalling downstream of activated mammalian Notch

Sophie Jarriault, Christel Brou, Frédérique Logeat, +3

Nature

Developmental BiologySignal TransductionSignaling PathwayMolecular RegulationCellular Regulatory Mechanism +6

Induction of mutant dynamin specifically blocks endocytic coated vesicle formation.

Hanna Damke, Toru Baba, Dale E. Warnock, +1

The Journal of Cell Biology

Molecular BiologyCoated VesiclesCellular PhysiologyEndocytic PathwayCell Signaling +16

A Novel Proteolytic Cleavage Involved in Notch Signaling

Christel Brou, Frédérique Logeat, Neetu Gupta, +7

Molecular Cell

Protein FunctionSignal TransductionSignaling PathwayReceptor Tyrosine KinaseCellular Biochemistry +4

SARA, a FYVE Domain Protein that Recruits Smad2 to the TGFβ Receptor

Tomoo Tsukazaki, Theodore Chiang, Anne Frances Davison, +2

Cell

Molecular PhysiologySignal TransductionSignaling PathwayRecruits Smad2Fyve Domain Protein +7

A Ligand-Induced Extracellular Cleavage Regulates γ-Secretase-like Proteolytic Activation of Notch1

Jeff S. Mumm, Eric H. Schroeter, Meera Saxena, +5

Molecular Cell

Protein FunctionSignal TransductionSignaling PathwayMolecular RegulationNatural Sciences +8

Structure-guided evolution of cyan fluorescent proteins towards a quantum yield of 93%

Joachim Goedhart, David von Stetten, Marjolaine Noirclerc‐Savoye, +6

Nature Communications

The Notch1 receptor is cleaved constitutively by a furin-like convertase

Frédérique Logeat, Christine Bessia, Christel Brou, +4

Proceedings of the National Academy of Sciences