ANTI-OBESITY ACTIVITY OF ZIZIPHUS MAURITIANA : A POTENT PANCREATIC LIPASE INHIBITOR

Abstract

The Anti-obesity activity of Ziziphus mauritiana Lam bark powder (ZMBP) on High Fat Diet (HFD) induced obesity in rats was studied. Obesity was induced in Wistar rats by feeding High Fat Diet (HFD) for 70 days. The rats were distributed in 5 groups (n=5) viz Normal Control, Obese Control, Obese rats with 250 mg/kg ZMBP , Obese rats with 500 mg/kg ZMBP, Obese rats with Sibutramine, 0.90 mg/kg treatment. The rats were dosed orally by gavage daily for a period of 90 days. At the end of 90 days treatment with ZMBP the obese rats showed 16.33 % reduction in body weight gain at 250 mg/kg dose, 17.38 % (p<0.05) reduction at 500 mg/kg dose and Sibutramine showed 5.52% reduction in body weight gain respectively when compared with the obese control group. The DEXA analysis at the end of 90 days of treatment showed 68.99 % (p<0.01) decrease in the Fat mass at 250 mg/kg dose and 72.84 % (p<0.001) decrease in the Fat mass at 500 mg/kg dose when compared with the obese control group. The pancreatic lipase activity in 250mg/kg and in 500 mg/kg reduced significantly (p<0.001) when compared with the obese control group.