Concepedia

Novel 7-Alkyl Methylenedioxy-Camptothecin Derivatives Exhibit Increased Cytotoxicity and Induce Persistent Cleavable Complexes Both with Purified Mammalian Topoisomerase I and in Human Colon Carcinoma SW620 Cells

Monica Valenti, Wilberto Nieves‐Neira, Glenda Kohlhagen, Kurt W. Kohn, Monroe E. Wall, Mansukh C. Wani, Yves Pommier

Molecular Pharmacology · 1997 · 34 citations · 32 references

DOI

Concepts

References

32

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.

Y H Hsiang, Robert Hertzberg, Sidney M. Hecht et al. · Journal of Biological Chemistry · 1985 · 2.4K citations · Full text

, , +15

Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin.

Y H Hsiang, M G Lihou, Leroy F. Liu · PubMed · 1989 · 1K citations

, , +17

Structure-activity study of the actions of camptothecin derivatives on mammalian topoisomerase I: evidence for a specific receptor site and a relation to antitumor activity.

Christine Jaxel, Kurt W. Kohn, Mansukh C. Wani et al. · PubMed · 1989 · 450 citations

, , +14

Camptothecin and taxol: discovery to clinic--thirteenth Bruce F. Cain Memorial Award Lecture.

Monroe E. Wall, Mansukh C. Wani · PubMed · 1995 · 373 citations

, , +16

Differential requirement of DNA replication for the cytotoxicity of DNA topoisomerase I and II inhibitors in Chinese hamster DC3F cells.

Connie Holm, Joseph M. Covey, Donna Kerrigan et al. · PubMed · 1989 · 370 citations

, , +13