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Potent quinoxaline-Based inhibitors of PDGF receptor tyrosine kinase activity. Part 1: SAR Exploration and Effective Bioisosteric Replacement of a phenyl substituent

Sar ExplorationMedicinal ChemistryMedicineRational Drug DesignPharmacotherapyAnti-cancer AgentDrug DevelopmentPotent Quinoxaline-based InhibitorsPharmacologyPharmaceutical ChemistryEffective Bioisosteric ReplacementBiomolecular EngineeringDrug Discovery