Novel histone deacetylase inhibitors: N-hydroxycarboxamides possessing a terminal bicyclic aryl group

Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A.

Minoru Yoshida, Masako Kijima, Motomu Akita et al. · Journal of Biological Chemistry · 1990 · 1.9K citations · Full text

Life Sciences, Molecular Biology, Pharmacology +17

A synthetic inhibitor of histone deacetylase, MS-27-275, with marked <i>in vivo</i> antitumor activity against human tumors

Akiko Saito, Takashi Yamashita, Yukiyasu Mariko et al. · Proceedings of the National Academy of Sciences · 1999 · 696 citations · Full text

Medicine, Oncology, Pharmacology +13

Suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase, suppresses the growth of prostate cancer cells in vitro and in vivo.

Lisa M. Butler, David B. Agus, Howard I. Scher et al. · PubMed · 2000 · 617 citations

Medicine, Oncology, Pharmacology +13

Trapoxin, an antitumor cyclic tetrapeptide, is an irreversible inhibitor of mammalian histone deacetylase.

Masako Kijima, Minoru Yoshida, Kenji Sugita et al. · Journal of Biological Chemistry · 1993 · 512 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14

FR901228, a Potent Antitumor Antibiotic, Is a Novel Histone Deacetylase Inhibitor

Hidenori Nakajima, Young Bae Kim, Hiroshi Terano et al. · Experimental Cell Research · 1998 · 487 citations

Medicine, Oncology, Pharmacology +8