Hidenori Nakajima

FK228 (depsipeptide) as a natural prodrug that inhibits class I histone deacetylases.

Ryohei Furumai, Akihisa Matsuyama, Nobuyuki Kobashi et al. · PubMed · 2002 · 744 citations

Life Sciences, Medicinal Chemistry, Pharmacology +13

Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA

Daisuke Kaida, Hajime Motoyoshi, Etsu Tashiro et al. · Nature Chemical Biology · 2007 · 655 citations

Life Sciences, Genetics, Molecular Biology +13

FR901228, a novel antitumor bicyclic depsipeptide produced by chromobacterium violaceum No. 968. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties, and antitumor activity.

Hirotsugu Ueda, Hidenori Nakajima, Yasuhiro Hori et al. · The Journal of Antibiotics · 1994 · 488 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +7

FR901228, a Potent Antitumor Antibiotic, Is a Novel Histone Deacetylase Inhibitor

Hidenori Nakajima, Young Bae Kim, Hiroshi Terano et al. · Experimental Cell Research · 1998 · 487 citations

Medicine, Oncology, Pharmacology +8

Identification of a selective ERK inhibitor and structural determination of the inhibitor–ERK2 complex

Makoto Ohori, Takayoshi Kinoshita, Mitsuru Okubo et al. · Biochemical and Biophysical Research Communications · 2005 · 225 citations

Life Sciences, Biochemistry, Medicinal Chemistry +16