Hidenori Nakajima

FK228 (depsipeptide) as a natural prodrug that inhibits class I histone deacetylases.

Ryohei Furumai, Akihisa Matsuyama, Nobuyuki Kobashi et al. · PubMed · 2002 · 744 citations

Reductive Stress, Disulfide Bond, Biochemistry +15

Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA

Daisuke Kaida, Hajime Motoyoshi, Etsu Tashiro et al. · Nature Chemical Biology · 2007 · 650 citations

Transcriptional Regulation, Systems Biology, Developmental Biology +10

FR901228, a Potent Antitumor Antibiotic, Is a Novel Histone Deacetylase Inhibitor

Hidenori Nakajima, Young Bae Kim, Hiroshi Terano et al. · Experimental Cell Research · 1998 · 486 citations

Medicinal Chemistry, Medicine, Natural Sciences +9

FR901228, a novel antitumor bicyclic depsipeptide produced by chromobacterium violaceum No. 968. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties, and antitumor activity.

Hirotsugu Ueda, Hidenori Nakajima, Yasuhiro Hori et al. · The Journal of Antibiotics · 1994 · 486 citations · Full text

Identification of a selective ERK inhibitor and structural determination of the inhibitor–ERK2 complex

Makoto Ohori, Takayoshi Kinoshita, Mitsuru Okubo et al. · Biochemical and Biophysical Research Communications · 2005 · 223 citations

Molecular Pharmacology, Medicinal Chemistry, Structural Determination +10