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SAR development of polycyclic guanine derivatives targeted to the discovery of a selective PDE5 inhibitor for treatment of erectile dysfunction

Dmitri Pissarnitski, Theodros Asberom, Craig D. Boyle, Samuel Chackalamannil, Madhu Chintala, John W. Clader, William J. Greenlee, Yue‐Qing Hu, Stanley Kurowski, Joyce Myers,

Bioorganic & Medicinal Chemistry Letters · 2004 · 22 citations · 9 references

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9

New aryl/heteroaryl CN bond cross-coupling reactions via arylboronic acid/cupric acetate arylation

Patrick Y. S. Lam, Charles G. Clark, Simon Saubern et al. · Tetrahedron Letters · 1998 · 1.1K citations

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Utilization of operational schemes for analog synthesis in drug design

John G. Topliss · Journal of Medicinal Chemistry · 1972 · 459 citations

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Erectile dysfunction: comparison of efficacy and side effects of the PDE-5 inhibitors sildenafil, vardenafil and tadalafil--review of the literature.

Ursula Gresser, C H Gleiter · PubMed · 2002 · 236 citations

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Potent Tetracyclic Guanine Inhibitors of PDE1 and PDE5 Cyclic Guanosine Monophosphate Phosphodiesterases with Oral Antihypertensive Activity

Ho-Sam Ahn, Ana Bercovici, George Boykow et al. · Journal of Medicinal Chemistry · 1997 · 80 citations · Full text

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N-3-Substituted Imidazoquinazolinones:  Potent and Selective PDE5 Inhibitors as Potential Agents for Treatment of Erectile Dysfunction

David P. Rotella, Zhong Sun, Yeheng Zhu et al. · Journal of Medicinal Chemistry · 2000 · 45 citations · Full text

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