Synthesis and cytotoxic activity of substituted 2-phenyl-3-hydroxy-4(1H)-quinolinones-7-carboxylic acids and their phenacyl esters

<i>SIR</i>97: a new tool for crystal structure determination and refinement

Angela Altomare, M. C. Burla, Mercedes Camalli et al. · Journal of Applied Crystallography · 1999 · 9.1K citations

Natural Sciences, Chemistry, Computational Chemistry +13

Cytotoxicity of quinolones toward eukaryotic cells. Identification of topoisomerase II as the primary cellular target for the quinolone CP-115,953 in yeast.

Sarah H. Elsea, Neil Osheroff, John L. Nitiss · Journal of Biological Chemistry · 1992 · 122 citations · Full text

Medicine, Molecular Biology, Pharmacology +17

Effects of novel fluoroquinolones on the catalytic activities of eukaryotic topoisomerase II: Influence of the C-8 fluorine group

Megan J. Robinson, Barbara A. Martin, Thomas D. Gootz et al. · Antimicrobial Agents and Chemotherapy · 1992 · 94 citations · Full text

Medicine, Molecular Biology, Pharmacology +14

Induction of calf thymus topoisomerase II-mediated DNA breakage by the antibacterial isothiazoloquinolones A-65281 and A-65282

W E Kohlbrenner, Norman E. Wideburg, D. Weigl et al. · Antimicrobial Agents and Chemotherapy · 1992 · 63 citations

Pharmacy, Molecular Biology, Pharmacology +15

Synthesis and Inhibitory Activity of Novel Tri- and Tetracyclic Quinolines against Topoisomerases

Zhihua Sui, Jason Altom, Van N. Nguyen et al. · Bioorganic & Medicinal Chemistry · 1998 · 48 citations

Natural Sciences, Chemistry, Medicinal Chemistry +14