Norman E. Wideburg

Design, Activity, and 2.8 Å Crystal Structure of a <i>C</i> ₂ Symmetric Inhibitor Complexed to HIV-1 Protease

John W. Erickson, David J. Neidhart, John H. VanDrie et al. · Science · 1990 · 528 citations · Full text

Characterization of human immunodeficiency virus type 1 variants with increased resistance to a C2-symmetric protease inhibitor

David D. Ho, T. TOYOSHIMA, Hongmei Mo et al. · Journal of Virology · 1994 · 212 citations · Full text

Immunology, Molecular Biology, Antiviral Drug +18

Structure-based, C2 symmetric inhibitors of HIV protease

Dale J. Kempf, Daniel W. Norbeck, LynnMarie Codacovi et al. · Journal of Medicinal Chemistry · 1990 · 211 citations · Full text

Altmetric Attention Score, Molecular Biology, Pharmacotherapy +19

Discovery of Ritonavir, a Potent Inhibitor of HIV Protease with High Oral Bioavailability and Clinical Efficacy

Dale J. Kempf, Hing L. Sham, Kennan C. Marsh et al. · Journal of Medicinal Chemistry · 1998 · 204 citations · Full text

Immunology, Pharmacotherapy, Antiviral Drug +18

Influence of stereochemistry on activity and binding modes for C2 symmetry-based diol inhibitors of HIV-1 protease

M.V. Hosur, Talapady N. Bhat, Dale J. Kempf et al. · Journal of the American Chemical Society · 1994 · 133 citations

Altmetric Attention Score, Antiviral Drug, Chemical Biology +18