miR-301a promotes intestinal mucosal inflammation through induction of IL-17A and TNF-α in IBD

Abstract

Our data reveal a novel mechanism in which the elevated miR-301a in PBMC and inflamed mucosa of IBD promotes Th17 cell differentiation through downregulation of SNIP1. Blockade of miR-301a in vivo may serve as a novel therapeutic approach in the treatment of IBD.