Synthesis of 1,5-disubstituted 4-haloimidazoles from α-aminonitriles

Chemistry of sulfonylmethyl isocyanides. 12. Base-induced cycloaddition of sulfonylmethyl isocyanides to carbon,nitrogen double bonds. Synthesis of 1,5-disubstituted and 1,4,5-trisubstituted imidazoles from aldimines and imidoyl chlorides

A. M. VAN LEUSEN, Jurjen Wildeman, O. H. OLDENZIEL · The Journal of Organic Chemistry · 1977 · 312 citations

Natural Sciences, Chemistry, Medicinal Chemistry +10

Synthesis and Structure−Activity Relationship of a New Series of COX-2 Selective Inhibitors:  1,5-Diarylimidazoles

Carmen Almansa, José Alfón, Alberto Fernández de Arriba et al. · Journal of Medicinal Chemistry · 2003 · 134 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

Pyrimidinylimidazole inhibitors of CSBP/P38 kinase demonstrating decreased inhibition of hepatic cytochrome P450 enzymes

Jerry L. Adams, Jeffrey C. Boehm, Shouki Kassis et al. · Bioorganic & Medicinal Chemistry Letters · 1998 · 113 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +16

A new synthesis of substituted 2(1<i>H</i>)‐pyrazinones

J.A.J.M. Vekemans, C. POLLERS‐WIEERS, Georges J. Hoornaert · Journal of Heterocyclic Chemistry · 1983 · 91 citations

Natural Sciences, Chemistry, Organic Chemistry +8

New Method for the Synthesis of Diversely Functionalized Imidazoles from N-Acylated α-Aminonitriles

Yong‐Li Zhong, Jaemoon Lee, Robert A. Reamer et al. · Organic Letters · 2004 · 63 citations

Natural Sciences, Chemistry, Medicinal Chemistry +9