A new synthesis of substituted 2(1<i>H</i>)‐pyrazinones

Abstract

Abstract The hydrohalides of 2‐ sec ‐aminoalkanenitriles on treatment with oxalyl halides in o ‐dichlorobenzene at 80‐100° give 3, 5‐dihalo‐2(1 H )‐pyrazinones, of which the 3‐halo substituent is easily replaced by nucleophiles. A reaction mechanism for the pyrazinone synthesis is proposed.