Synthesis and SAR of a New Series of COX-2-Selective Inhibitors:  Pyrazolo[1,5-<i>a</i>]pyrimidines

Carmen Almansa, Alberto Fernández de Arriba, Fernando L. Cavalcanti, +5

Journal of Medicinal Chemistry

Cox-2-selective InhibitorsMedicinal ChemistryCox-2 InhibitionPharmaceutical ScienceSelective Cox-2 Inhibitor +13

Co-crystal of Tramadol Hydrochloride–Celecoxib (<b>ctc</b>): A Novel API–API Co-crystal for the Treatment of Pain

Carmen Almansa, Ramon Mercè, Nicolas Tesson, +3

Crystal Growth & Design

Pharmaceutical SciencePain DisordersTramadol Hydrochloride–celecoxibPain MedicinePharmacotherapy +20

Synthesis and Structure−Activity Relationship of a New Series of COX-2 Selective Inhibitors:  1,5-Diarylimidazoles

Carmen Almansa, José Alfón, Alberto Fernández de Arriba, +9

Journal of Medicinal Chemistry

Organic ChemistryPharmacotherapyNew SeriesHeterocycle ChemistryPharmaceutical Chemistry +14

Synthesis and Biological Evaluation of the 1-Arylpyrazole Class of σ₁ Receptor Antagonists: Identification of 4-{2-[5-Methyl-1-(naphthalen-2-yl)-1<i>H</i>-pyrazol-3-yloxy]ethyl}morpholine (S1RA, E-52862)

José Luis Dı́az, Rosa Cuberes, Joana Berrocal, +13

Journal of Medicinal Chemistry

Spacer LengthsPharmacotherapyNew SeriesChemical BiologyExperimental Pharmacology +16

Synthesis and Structure−Activity Relationship of a New Series of Potent AT₁ Selective Angiotensin II Receptor Antagonists:  5-(Biphenyl-4-ylmethyl)pyrazoles

Carmen Almansa, Luis Alberto Gómez, Fernando L. Cavalcanti, +3

Journal of Medicinal Chemistry

A New Pharmacophore Model for the Design of Sigma-1 Ligands Validated on a Large Experimental Dataset

Rosalía Pascual, Carmen Almansa, Carlos R. Plata‐Saláman, +1

Frontiers in Pharmacology

Theoretical Studies on the Inhibition Mechanism of Cyclooxygenase-2. Is There a Unique Recognition Site?

Robert Soliva, Carmen Almansa, Susana G. Kalko, +2

Journal of Medicinal Chemistry

Aldo-keto ReductaseSubtle Structural ChangesChemical BiologyMolecular DynamicsRedox Biology +16

A potent and selective p38 inhibitor protects against bone damage in murine collagen‐induced arthritis: a comparison with neutralization of mouse TNFα

Katsuhiro Mihara, Carmen Almansa, Ruben L. Smeets, +8

British Journal of Pharmacology

Synthesis and structure-activity relationships of 1-acyl-4-((2-methyl-3-pyridyl)cyanomethyl)piperazines as PAF antagonists

Elena Carceller, Manuel Merlos, Marta Giral, +4

Journal of Medicinal Chemistry

Synthesis and Structure–Activity Relationship Study of a New Series of Selective σ₁Receptor Ligands for the Treatment of Pain: 4-Aminotriazoles

José Luis Dı́az, Ute Christmann, Ariadna Fernández, +10

Journal of Medicinal Chemistry