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Novel thrombin inhibitors incorporating non-basic partially saturated heterobicyclic P1-Arginine mimetics

Lucíja Peterlin Mašič, Gregor Mlinšek, Tomaž Šolmajer, Alenka Trampuš-Bakija, Mojca Stegnar, D. Kikelj

Bioorganic & Medicinal Chemistry Letters · 2003 · 17 citations · 24 references

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Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

, , +14

The refined 1.9 A crystal structure of human alpha‐thrombin: interaction with D‐Phe‐Pro‐Arg chloromethylketone and significance of the Tyr‐Pro‐Pro‐Trp insertion segment.

Wolfram Bode, Irmgard Mayr, Ulrich Baumann et al. · The EMBO Journal · 1989 · 893 citations · Full text

, , +6

Structure-Based Design of Novel Potent Nonpeptide Thrombin Inhibitors

Norbert Hauel, Herbert Nar, Henning Priepke et al. · Journal of Medicinal Chemistry · 2002 · 451 citations · Full text

, , +16

Design and Synthesis of Potent and Highly Selective Thrombin Inhibitors

Kurt Hilpert, Jean Ackermann, David W. Banner et al. · Journal of Medicinal Chemistry · 1994 · 190 citations · Full text

, , +13

Bicyclic and tricyclic ergoline partial structures. Rigid 3-(2-aminoethyl)pyrroles and 3- and 4-(2-aminoethyl)pyrazoles as dopamine agonists

Nicholas J. Bach, Edmund C. Kornfeld, Noel D. Jones et al. · Journal of Medicinal Chemistry · 1980 · 170 citations

, , +15