Concepedia

Preparation and optimization of pyrazolo[1,5-a]pyrimidines as new potent PDE4 inhibitors

Jacques Le Roux, Caroline Leriche, Philippe Chamiot‐Clerc, John T. Feutrill, Frank Halley, David Papin, Nathalie Derimay, Christelle Mugler, Claudine Grépin, Laurent Schio

Bioorganic & Medicinal Chemistry Letters · 2015 · 31 citations · 19 references

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19

Motifs for molecular recognition exploiting hydrophobic enclosure in protein–ligand binding

Tom Young, Robert Abel, Byungchan Kim et al. · Proceedings of the National Academy of Sciences · 2007 · 707 citations · Full text

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Role of the Active-Site Solvent in the Thermodynamics of Factor Xa Ligand Binding

Robert Abel, Tom Young, Ramy Farid et al. · Journal of the American Chemical Society · 2008 · 677 citations · Full text

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Computational methods for the prediction of ‘drug-likeness’

David E. Clark, Stephen D. Pickett · Drug Discovery Today · 2000 · 573 citations

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Mechanism of the hydrophobic effect in the biomolecular recognition of arylsulfonamides by carbonic anhydrase

Phillip W. Snyder, Jasmin Mecinović, Demetri T. Moustakas et al. · Proceedings of the National Academy of Sciences · 2011 · 359 citations · Full text

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Energetics of Displacing Water Molecules from Protein Binding Sites: Consequences for Ligand Optimization

Julien Michel, Julian Tirado‐Rives, William L. Jorgensen · Journal of the American Chemical Society · 2009 · 265 citations · Full text

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