Laurent Schio

A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy

Baptiste Ronan, Odile Flamand, Lionel Vescovi et al. · Nature Chemical Biology · 2014 · 486 citations

Life Sciences, Medicinal Chemistry, Molecular Biology +12

N-Heterocyclic Carbene-Amine Pt(II) Complexes, a New Chemical Space for the Development of Platinum-Based Anticancer Drugs

Myriem Skander, Pascal Retailleau, Bernard Bourrié et al. · Journal of Medicinal Chemistry · 2010 · 171 citations

Medicine, Medicinal Chemistry, Oncology +13

Discovery of (2<i>S</i>)-8-[(3<i>R</i>)-3-Methylmorpholin-4-yl]-1-(3-methyl-2-oxobutyl)-2-(trifluoromethyl)-3,4-dihydro-2<i>H</i>-pyrimido[1,2-<i>a</i>]pyrimidin-6-one: A Novel Potent and Selective Inhibitor of Vps34 for the Treatment of Solid Tumors

Benoit Pasquier, Youssef El‐Ahmad, Bruno Filoche-Rommé et al. · Journal of Medicinal Chemistry · 2014 · 92 citations

Pharmacy, Medicinal Chemistry, Pharmacology +13

Tosylates in palladium-catalysed coupling reactions. Application to the synthesis of arylcoumarin inhibitors of gyrase B

Laurent Schio, Fabienne Chatreaux, Michel Klich · Tetrahedron Letters · 2000 · 89 citations

Pharmacy, Chemistry, Medicinal Chemistry +7

Discovery and Optimization of Pyrimidone Indoline Amide PI3Kβ Inhibitors for the Treatment of Phosphatase and Tensin Homologue (PTEN)-Deficient Cancers

Victor Certal, Jean‐Christophe Carry, Frank Halley et al. · Journal of Medicinal Chemistry · 2014 · 85 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15