1-Phenyl-8-azabicyclo[3.2.1]octane ethers: A novel series of neurokinin (NK1) antagonists

A Potent Nonpeptide Antagonist of the Substance P (NK ₁ ) Receptor

R. Michael Snider, Jay W. Constantine, John Lowe et al. · Science · 1991 · 864 citations

Medicine, Medicinal Chemistry, Pharmacology +14

Titanium-mediated carbonyl olefinations. 1. Methylenations of carbonyl compounds with dimethyltitanocene

Nicos A. Petasis, Eugene I. Bzowej · Journal of the American Chemical Society · 1990 · 534 citations

Natural Sciences, Chemistry, Catalysis +5

Structural Optimization Affording 2-(<i>R</i>)-(1-(<i>R</i>)-3,5-Bis(trifluoromethyl)phenylethoxy)-3-(<i>S</i>)-(4-fluoro)phenyl-4- (3-oxo-1,2,4-triazol-5-yl)methylmorpholine, a Potent, Orally Active, Long-Acting Morpholine Acetal Human NK-1 Receptor Antagonist

Jeffrey J. Hale, Sander G. Mills, Malcolm MacCoss et al. · Journal of Medicinal Chemistry · 1998 · 205 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Characterization of the binding of a potent, selective, radioiodinated antagonist to the human neurokinin-1 receptor.

Margaret A. Cascieri, E Ber, Tung M. Fong et al. · Molecular Pharmacology · 1992 · 137 citations

Medicine, Medicinal Chemistry, Pharmacology +12

Piperidine-ether based hNK1 antagonists 1: Determination of the relative and absolute stereochemical requirements

Timothy Harrison, Brian J. Williams, Christopher J. Swain et al. · Bioorganic & Medicinal Chemistry Letters · 1994 · 125 citations

Pharmacy, Medicinal Chemistry, Pharmacology +12