Timothy Harrison

Distinct Mechanism for Antidepressant Activity by Blockade of Central Substance P Receptors

Mark S. Kramer, Neal R. Cutler, John P. Feighner et al. · Science · 1998 · 1.1K citations

Psychotropic Medication, Psychopharmacology, Antidepressant Activity +16

Discovery and characterization of highly potent and selective allosteric USP7 inhibitors

Gérald Gavory, C. O'Dowd, Matthew Helm et al. · Nature Chemical Biology · 2017 · 219 citations · Full text

Molecular Docking, Drug Target, Biochemistry +7

Pharmacological blockade or genetic deletion of substance P (NK1) receptors attenuates neonatal vocalisation in guinea-pigs and mice

N.M.J. Rupniak, E.C Carlson, Timothy Harrison et al. · Neuropharmacology · 2000 · 171 citations

Molecular Pharmacology, Neonatal Vocalisation, Genetic Deletion +10

Comparison of the phenotype of NK1R−/− mice with pharmacological blockade of the substance P (NK 1 ) receptor in assays for antidepressant and anxiolytic drugs

N.M.J. Rupniak, Emma Carlson, J.K. Webb et al. · Behavioural Pharmacology · 2001 · 150 citations

Nk1 Receptor, Nk1r−/− Mice, Nk 1 +19

Apoptosis in T Cell Acute Lymphoblastic Leukemia Cells after Cell Cycle Arrest Induced by Pharmacological Inhibition of Notch Signaling

Huw D. Lewis, Matthew Leveridge, Peter R. Strack et al. · Chemistry & Biology · 2007 · 148 citations

Hematological Malignancy, Mixed-phenotype Acute Leukemia, Malignant Blood Disorder +10