N.M.J. Rupniak

Distinct Mechanism for Antidepressant Activity by Blockade of Central Substance P Receptors

Mark S. Kramer, Neal R. Cutler, John P. Feighner et al. · Science · 1998 · 1.1K citations

Psychotropic Medication, Psychopharmacology, Antidepressant Activity +16

The discovery of rofecoxib, [MK 966, VIOXX®, 4-(4′-methylsulfonylphenyl)-3-phenyl-2(5H)-furanone], an orally active cyclooxygenase-2 inhibitor

Petpiboon Prasit, Z Wang, Christine Brideau et al. · Bioorganic & Medicinal Chemistry Letters · 1999 · 426 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Active Cyclooxygenase-2 Inhibitor +10

Selective NMDA NR2B antagonists induce antinociception without motor dysfunction: correlation with restricted localisation of NR2B subunit in dorsal horn

S. Boyce, A. C. Wyatt, J.K. Webb et al. · Neuropharmacology · 1999 · 336 citations

Motor Dysfunction, Health Sciences, Selective Nmda Nr2b +14

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in the common marmoset

Peter Jenner, N.M.J. Rupniak, Sarah Rose et al. · Neuroscience Letters · 1984 · 324 citations

Medicine, Parkinson Disease, Neuropharmacology +5

Genetic knockout and pharmacological blockade studies of the 5-HT7 receptor suggest therapeutic potential in depression

Martin R. Guscott, Linda J. Bristow, Karen L. Hadingham et al. · Neuropharmacology · 2005 · 227 citations

Psychiatry, Functional Selectivity, Medicine +12