Concepedia

SWI/SNF proteins as targets in cancer therapy

Santiago Schiaffino‐Ortega, Carlos Baliñas-Gavira, Marta Cuadros, Pedro P. Medina

Journal of Hematology & Oncology · 2014 · 18 citations · 11 references

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Concepts

Abstract

Recent identification of synthetic lethal interactions involving several proteins of the SWI/SNF complex discussed in this Research Highlight has opened the possibility of new cancer therapeutic approaches.

References

11

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

Mark A. Dawson, Rab K. Prinjha, Antje Dittmann et al. · Nature · 2011 · 1.5K citations · Full text

, , +10

Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated <i>Myc</i> regulation

Junwei Shi, Warren A. Whyte, Cinthya Zepeda‐Mendoza et al. · Genes & Development · 2013 · 458 citations · Full text

, , +17

ARID1B is a specific vulnerability in ARID1A-mutant cancers

Katherine Helming, Xiaofeng Wang, Boris G. Wilson et al. · Nature Medicine · 2014 · 430 citations · Full text

, , +14

Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers

Gregory R. Hoffman, Rami Rahal, Frank P. Buxton et al. · Proceedings of the National Academy of Sciences · 2014 · 416 citations · Full text

, , +17

A Synthetic Lethality–Based Strategy to Treat Cancers Harboring a Genetic Deficiency in the Chromatin Remodeling Factor BRG1

Takahiro Oike, Hideaki Ogiwara, Yuichi Tominaga et al. · Cancer Research · 2013 · 302 citations · Full text

, , +17