Concepedia

Heterocyclic thrombin inhibitors. Part 2: quinoxalinone derivatives as novel, potent antithrombotic agents

Uwe J. Ries, Henning Priepke, Norbert Hauel, Sandra Handschuh, Gerhard Mihm, Jean Marie Stassen, Wolfgang Wienen, Herbert Nar

Bioorganic & Medicinal Chemistry Letters · 2003 · 78 citations · 10 references

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10

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

Axel T. Brünger, Paul D. Adams, G. Marius Clore et al. · Acta Crystallographica Section D Biological Crystallography · 1998 · 15.8K citations

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MMFF VI. MMFF94s option for energy minimization studies

Thomas A. Halgren · Journal of Computational Chemistry · 1999 · 1.2K citations

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Maximally diagonal force constants in dependent angle-bending coordinates. II. Implications for the design of empirical force fields

Thomas A. Halgren · Journal of the American Chemical Society · 1990 · 166 citations

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Geometry of binding of the benzamidine‐ and arginine‐based inhibitors <i>N</i><sup>α</sup>‐(2‐naphthyl‐sulphonyl‐glycyl)‐<scp>dl</scp>‐<i>p</i>‐amidinophenylalanyl‐piperidine (NAPAP) and (2<i>R</i>,4<i>R</i>)‐4‐methyl‐1‐[<i>N</i><sup>α</sup>‐(3‐methyl‐1,2,3,4‐tetrahydro‐8‐quinolinesulphonyl)‐<scp>l</scp>‐arginyl]‐2‐piperidine carboxylic acid (MQPA) to human α‐thrombin

Wolfram Bode, Jörg Stürzebecher · European Journal of Biochemistry · 1990 · 124 citations · Full text

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Crystal structures of factor Xa specific inhibitors in complex with trypsin: structural grounds for inhibition of factor Xa and selectivity against thrombin

Milton T. Stubbs, Robert Huber, Wolfram Bode · FEBS Letters · 1995 · 102 citations · Full text

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