Sandra Handschuh

Design, Synthesis, and Evaluation of Indolinones as Triple Angiokinase Inhibitors and the Discovery of a Highly Specific 6-Methoxycarbonyl-Substituted Indolinone (BIBF 1120)

Gerald J. Roth, Armin Heckel, Florian Colbatzky et al. · Journal of Medicinal Chemistry · 2009 · 234 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +16

Superposition of Three-Dimensional Chemical Structures Allowing for Conformational Flexibility by a Hybrid Method

Sandra Handschuh, Markus Wagener, Johann Gasteiger · Journal of Chemical Information and Computer Sciences · 1998 · 89 citations

Pharmacy, Medicinal Chemistry, Pharmacology +10

Heterocyclic thrombin inhibitors. Part 2: quinoxalinone derivatives as novel, potent antithrombotic agents

Uwe J. Ries, Henning Priepke, Norbert Hauel et al. · Bioorganic & Medicinal Chemistry Letters · 2003 · 78 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +15

Stabilizing of a Globular Protein by a Highly Complex Water Network: A Molecular Dynamics Simulation Study on Factor Xa

Hannes G. Wallnoefer, Sandra Handschuh, Klaus R. Liedl et al. · The Journal of Physical Chemistry B · 2010 · 71 citations

Natural Sciences, Biochemistry, Biophysics +16

Discovery of BI-2545: A Novel Autotaxin Inhibitor That Significantly Reduces LPA Levels in Vivo

Christian A. Kuttruff, Marco Ferrara, Tom Bretschneider et al. · ACS Medicinal Chemistry Letters · 2017 · 43 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +10