Structure-Based Design of Novel Potent Nonpeptide Thrombin Inhibitors

Norbert Hauel, Herbert Nar, Henning Priepke, +3

Journal of Medicinal Chemistry

Chemical BiologyPharmaceutical ChemistryThrombosisMedicinal ChemistryThrombin Inhibition +14

6-Substituted benzimidazoles as new nonpeptide angiotensin II receptor antagonists: synthesis, biological activity, and structure-activity relationships

Uwe J. Ries, Gerhard Mihm, Berthold Narr, +6

Journal of Medicinal Chemistry

Biological ActivityMedicinal ChemistryBibr 277Drug TargetBiochemistry +13

Pharmacological characterization of the novel nonpeptide angiotensin II receptor antagonist, BIBR 277

Wolfgang Wienen, Norbert Hauel, J. C. A. van Meel, +3

British Journal of Pharmacology

HypertensionPharmacological CharacterizationCardiovascular PharmacologyRenal InflammationPharmacotherapy +17

Structural Basis for Inhibition Promiscuity of Dual Specific Thrombin and Factor Xa Blood Coagulation Inhibitors

Herbert Nar, M. R. Bauer, Angela Schmid, +6

Structure

ThrombopoiesisThrombosisBiochemistryBlood PlateletMedicine +9

Heterocyclic thrombin inhibitors. Part 2: quinoxalinone derivatives as novel, potent antithrombotic agents

Uwe J. Ries, Henning Priepke, Norbert Hauel, +5

Bioorganic & Medicinal Chemistry Letters

ThrombopoiesisThrombosisMedicinal ChemistryHeterocyclic Thrombin InhibitorsQuinoxalinone Derivatives +10

Antithrombotic and anticoagulant effects of the direct thrombin inhibitor dabigatran, and its oral prodrug, dabigatran etexilate, in a rabbit model of venous thrombosis

Wolfgang Wienen, J M Stassen, Henning Priepke, +2

Journal of Thrombosis and Haemostasis

Characterization and Comparative Evaluation of a Novel PAI-1 Inhibitor

Ann Gils, Jean–Marie Stassen, Herbert Nar, +3

Thrombosis and Haemostasis

ThrombosisMedicinal ChemistryPlasminogen Activator Inhibitor-1BiochemistryMedicine +11

Serine proteases as targets for antithrombotic therapy

Uwe J. Ries, Wolfgang Wienen

Drugs of the Future

Serine ProteasesPharmacotherapyHemostatic SystemThrombosisTranslational Medicine +18

Heterocyclic thrombin inhibitors. Part 1: design and synthesis of amidino-phenoxy quinoline derivatives

Uwe J. Ries, Henning Priepke, Norbert Hauel, +4

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryHeterocyclic Thrombin InhibitorsBioorganic ChemistryBiochemistryNatural Sciences +8

In vitro and in vivo antitumoral activity of alkylphosphonates

Uwe J. Ries, E. A. M. Fleer, A. Breiser, +4

European Journal of Cancer

Medicinal ChemistryMedicineVivo Antitumoral ActivityAnti-cancer AgentPharmacology +2