Pharmacodynamic resistance to warfarin is associated with nucleotide substitutions inVKORC1

Effect of <i>VKORC1</i> Haplotypes on Transcriptional Regulation and Warfarin Dose

Mark J. Rieder, Alexander P. Reiner, Brian F. Gage et al. · New England Journal of Medicine · 2005 · 1.4K citations · Full text

Bleeding complications of oral anticoagulant treatment: an inception-cohort, prospective collaborative study (ISCOAT)

Gualtiero Palareti, Nicoletta Leali, S Coccheri et al. · The Lancet · 1996 · 1.3K citations

Thrombosis, Venous Thrombosis, Cardiovascular Disease +14

Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2

Simone Rost, Andreas Fregin, Vytautas Ivaškevičius et al. · Nature · 2004 · 1.1K citations

Thrombosis, Disease Mechanism, Genetic Disorder +10

The impact of CYP2C9 and VKORC1 genetic polymorphism and patient characteristics upon warfarin dose requirements: proposal for a new dosing regimen

Elizabeth Sconce, Tayyaba Khan, Hilary Wynne et al. · Blood · 2005 · 945 citations · Full text

Identification of the gene for vitamin K epoxide reductase

Tao Li, Chun-Yun Chang, Da-Yun Jin et al. · Nature · 2004 · 705 citations

Biosynthesis, Aldo-keto Reductase, Biochemistry +6