Instability of chromosome structure in cancer cells increases exponentially with degrees of aneuploidy

The Clonal Evolution of Tumor Cell Populations

Peter C. Nowell̀ · Science · 1976 · 6.5K citations

Medicine, Genetics, Oncology +17

Genetic instability in colorectal cancers

Christoph Lengauer, Kenneth W. Kinzler, Bert Vogelstein · Nature · 1997 · 2K citations

Medicine, Genetics, Molecular Genetics +14

Genomic Instability in Mice Lacking Histone H2AX

Arkady Celeste, Simone Petersen, Peter Romanienko et al. · Science · 2002 · 1.4K citations · Full text

Life Sciences, Genetics, Molecular Biology +17

Mutator phenotype may be required for multistage carcinogenesis.

L A Loeb · PubMed · 1991 · 1.3K citations

Medicine, Genetics, Molecular Genetics +11

SEGMENTAL ANEUPLOIDY AND THE GENETIC GROSS STRUCTURE OF THE DROSOPHILA GENOME

Dan L. Lindsley, L Sandler, Bruce S. Baker et al. · Genetics · 1972 · 611 citations · Full text

Life Sciences, Genetics, Molecular Genetics +13