Concepedia

Chromosome Instability

Chromosome Instability is a type of genomic instability characterized by an increased rate of gain or loss of whole chromosomes or chromosomal segments due to defects in mitotic chromosome segregation, DNA repair, or cell cycle control mechanisms.

909

Publications

70.3K

Citations

4.9K

Authors

1.3K

Institutions

Publications per year

2017–2026

170

Parents

Publications

909

Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.

Christopher M. Counter, Ariel A. Avilion, Catherine LeFeuvre et al. · The EMBO Journal · 1992 · 2.1K citations · Full text

, , +14

Chromosomal instability drives metastasis through a cytosolic DNA response

Samuel F. Bakhoum, Bryan Ngo, Ashley M. Laughney et al. · Nature · 2018 · 1.6K citations

, , +14

DNA breaks and chromosome pulverization from errors in mitosis

Karen Crasta, Neil J. Ganem, Regina Dagher et al. · Nature · 2012 · 1.2K citations

, , +14

A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers

Scott L. Carter, Aron C. Eklund, Isaac S. Kohane et al. · Nature Genetics · 2006 · 1.2K citations

, , +17

Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene

Guoliang Xu, Timothy H. Bestor, Déborah Bourc’his et al. · Nature · 1999 · 1.2K citations

, , +16

1–5 of 909

Authors

4.9K

  1. KJ
    Kirk J. McManus

    University of Manitoba, Canada

    20 publications · 1.3K citations

    18

    h-index

  2. PH
    Philip Hieter

    Johns Hopkins University, United States

    18 publications · 1.9K citations

    16

    h-index

  3. ZL
    Zelda Lichtensztejn

    University of Manitoba, Canada

    11 publications · 384 citations

    11

    h-index

  4. SG
    Svetlana G. Vorsanova

    Mental Health Research Center of Russian Academy of Medical Sciences, Russia

    10 publications · 680 citations

    10

    h-index

  5. IY
    Ivan Y. Iourov

    Mental Health Research Center of Russian Academy of Medical Sciences, Russia

    10 publications · 680 citations

    10

    h-index

1–5 of 4.9K

Institutions

1.3K

  1. Harvard University

    Cambridge, United States

    25 h-index

    88 publications

    19.5K citations

  2. University of California, San Francisco

    San Francisco, United States

    20 h-index

    65 publications

    7.8K citations

  3. Johns Hopkins University

    Baltimore, United States

    18 h-index

    81 publications

    17.8K citations

  4. Inserm

    Paris, France

    17 h-index

    106 publications

    11.9K citations

  5. Memorial Sloan Kettering Cancer Center

    New York, United States

    17 h-index

    71 publications

    31.1K citations

  6. University of Washington

    Seattle, United States

    17 h-index

    71 publications

    6K citations

  7. Centre National de la Recherche Scientifique

    Paris, France

    17 h-index

    83 publications

    4.5K citations

  8. University of British Columbia

    Vancouver, Canada

    16 h-index

    63 publications

    7.1K citations

1–8 of 1.3K

Venues

  1. PubMed

    Repository · 49 publications · 3.7K citations

    29

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 31 publications · 5.2K citations

    29

    h-index

  3. Cancer Research

    29 publications · 1.8K citations

    24

    h-index

  4. Molecular and Cellular Biology

    MCB · 23 publications · 2.5K citations

    21

    h-index

  5. Cancer Genetics and Cytogenetics

    23 publications · 746 citations

    17

    h-index

1–5