Whole Genome Characterization of the Mechanisms of Daptomycin Resistance in Clinical and Laboratory Derived Isolates of Staphylococcus aureus

Anton Y. Peleg, Spiros Miyakis, Doyle V. Ward, Ashlee M. Earl, Aileen Rubio, David R. Cameron, Satish K. Pillai, Robert C. Moellering, George M. Eliopoulos

PLoS ONE · 2012 · 241 citations · 31 references

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Abstract

Point mutations in genes coding for membrane phospholipids are associated with the development of reduced susceptibility to daptomycin in S. aureus. Mutations in cls2 and pgsA appear to be new genetic mechanisms affecting daptomycin susceptibility in S. aureus.

References

31