Concepedia

An Integrated Approach to the Prediction of Systemic Toxicity using Computer-based Biokinetic Models and Biological In vitro Test Methods: Overview of a Prevalidation Study Based on the ECITTS Project

Joost DeJongh, Anna Forsby, J. Brian Houston, Marie Beckman, Robert D. Combes, Bas J. Blaauboer

Toxicology in Vitro · 1999 · 66 citations · 9 references

DOI

Concepts

References

9

A physiologically based description of the inhalation pharmacokinetics of styrene in rats and humans

J.C. Ramsey, Melvin E. Andersen · Toxicology and Applied Pharmacology · 1984 · 675 citations

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A quantitative property-property relationship (QPPR) approach to estimate in vitro tissue-blood partition coefficients of organic chemicals in rats and humans

Joost DeJongh, Henk J. M. Verhaar, Joop L. M. Hermens · Archives of Toxicology · 1997 · 167 citations

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Estimation of Systemic Toxicity of Acrylamide by Integration of in Vitro Toxicity Data with Kinetic Simulations

Joost DeJongh, Marika Nordin-Andersson, Bart A. Ploeger et al. · Toxicology and Applied Pharmacology · 1999 · 72 citations

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Simulation of Toluene Kinetics in the Rat by a Physiologically Based Pharmacokinetic Model with Application of Biotransformation Parameters Derived Independentlyin Vitroandin Vivo

Joost DeJongh · Fundamental and Applied Toxicology · 1996 · 34 citations

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Role of Kinetics in Acute Lethality of Nonreactive Volatile Organic Compounds (VOCs)

Joost DeJongh, Henk J. M. Verhaar, Joop L. M. Hermens · Toxicological Sciences · 1998 · 33 citations

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