Direct Interaction of Kindlin-3 With Integrin αIIbβ3 in Platelets Is Required for Supporting Arterial Thrombosis in Mice

Abstract

These observations demonstrate that the direct binding of kindlin-3 to integrin αIIbβ3 is involved in supporting integrin αIIbβ3 activation and integrin αIIbβ3-dependent responses of platelets and consequently contributes significantly to arterial thrombus formation.