Concepedia

The Microtubule-Stabilizing Agent Discodermolide Competitively Inhibits the Binding of Paclitaxel (Taxol) to Tubulin Polymers, Enhances Tubulin Nucleation Reactions More Potently than Paclitaxel, and Inhibits the Growth of Paclitaxel-Resistant Cells

Richard Kowalski, Paraskevi Giannakakou, Sarath P. Gunasekera, Ross E. Longley, Billy W. Day, Ernest Hamel

Molecular Pharmacology · 1997 · 262 citations · 30 references

References

30

New Colorimetric Cytotoxicity Assay for Anticancer-Drug Screening

Philip Skehan, Ritsa Storeng, Dominic A. Scudiero et al. · JNCI Journal of the National Cancer Institute · 1990 · 9.8K citations

Medicine, Oncology, Pharmacology +10

Promotion of microtubule assembly in vitro by taxol

Peter B. Schiff, Jane Fant, Susan Band Horwitz · Nature · 1979 · 3.6K citations

Life Sciences, Biochemistry, Cell Biology +9

Mechanism of mitotic block and inhibition of cell proliferation by taxol at low concentrations.

Mary Ann Jordan, Robert Toso, Douglas Thrower et al. · Proceedings of the National Academy of Sciences · 1993 · 1.1K citations · Full text

Life Sciences, Cell Biology, Pharmacology +17

Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action

Suzanne B. Buck, Sam F. Victory, Richard H. Himes et al. · 1998 · 983 citations

Pharmacy, Medicinal Chemistry, Pharmacology +10

Paclitaxel-resistant Human Ovarian Cancer Cells Have Mutant β-Tubulins That Exhibit Impaired Paclitaxel-driven Polymerization

Paraskevi Giannakakou, Dan L. Sackett, Yoon‐Koo Kang et al. · Journal of Biological Chemistry · 1997 · 682 citations · Full text

Medicine, Oncology, Pharmacology +12