Modular Assembly of Glycoproteins: Towards the Synthesis of GlyCAM‐1 by Using Expressed Protein Ligation

Abstract

Put the two together: Physiologically relevant glycoproteins containing saccharides at predetermined sites, such as GlyCAM-1, can be generated from small synthetic and bacterially derived fragments by using the expressed protein ligation methodology. This technique was used for the synthesis of three semisynthetic GlyCAM-1 variants 1–3 (see scheme). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2004/z52673_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.