Concepedia

Dose-Dependent Interaction between Gemfibrozil and Repaglinide in Humans: Strong Inhibition of CYP2C8 with Subtherapeutic Gemfibrozil Doses

Johanna Honkalammi, Mikko Niemi, Pertti J. Neuvonen, Janne T. Backman

Drug Metabolism and Disposition · 2011 · 76 citations · 34 references

DOI

Concepts

References

34

Drug and Bile Acid Transporters in Rosuvastatin Hepatic Uptake: Function, Expression, and Pharmacogenetics

Richard Ho, Rommel G. Tirona, Brenda F. Leake et al. · Gastroenterology · 2006 · 610 citations · Full text

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Gemfibrozil and Its Glucuronide Inhibit the Organic Anion Transporting Polypeptide 2 (OATP2/OATP1B1:SLC21A6)-Mediated Hepatic Uptake and CYP2C8-Mediated Metabolism of Cerivastatin: Analysis of the Mechanism of the Clinically Relevant Drug-Drug Interaction between Cerivastatin and Gemfibrozil

Yoshihisa Shitara, Masaru Hirano, Hitoshi Sato et al. · Journal of Pharmacology and Experimental Therapeutics · 2004 · 405 citations

, , +17

Selective biotransformation of taxol to 6 alpha-hydroxytaxol by human cytochrome P450 2C8.

Atiqur Rahman, Ken Korzekwa, James Grogan et al. · PubMed · 1994 · 391 citations

, , +17

Polymorphic organic anion transporting polypeptide 1B1 is a major determinant of repaglinide pharmacokinetics

Mikko Niemi, Janne T. Backman, Lauri Kajosaari et al. · Clinical Pharmacology & Therapeutics · 2005 · 361 citations

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Gemfibrozil greatly increases plasma concentrations of cerivastatin

Janne T. Backman · Clinical Pharmacology & Therapeutics · 2002 · 336 citations

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