Functional Characterization of CYP2B6 Allelic Variants in Demethylation of Antimalarial Artemether

CYP2B6 Mediates the In Vitro Hydroxylation of Bupropion: Potential Drug Interactions with Other Antidepressants

L M Hesse, Karthik Venkatakrishnan, Michael H. Court et al. · Drug Metabolism and Disposition · 2000 · 399 citations

Medicine, Biochemistry, Pharmacology +17

Development of a Substrate-Activity Based Approach To Identify the Major Human Liver P-450 Catalysts of Cyclophosphamide and Ifosfamide Activation Based on cDNA-Expressed Activities and Liver Microsomal P-450 Profiles

Partha Pratim Roy, L J Yu, Charles L. Crespi et al. · Drug Metabolism and Disposition · 1999 · 319 citations

Medicine, Biochemistry, Pharmacology +17

Fatal Neurotoxicity of Arteether and Artemether

Thomas G. Brewer, Stephen J. Grate, James O. Peggins et al. · American Journal of Tropical Medicine and Hygiene · 1994 · 275 citations

Pharmacy, Neurology, Toxicology +13

Genetic variability of CYP2B6 in populations of African and Asian origin: allele frequencies, novel functional variants, and possible implications for anti-HIV therapy with efavirenz

Kathrin Klein, Thomas Lang, Eduardo Barbosa‐Sicard et al. · Pharmacogenetics and Genomics · 2005 · 269 citations

Life Sciences, Genetics, Pharmacology +16

Polymorphic<i>CYP2B6</i>: Molecular Mechanisms and Emerging Clinical Significance

Ulrich M. Zanger, Kathrin Klein, Julia Blievernicht et al. · Pharmacogenomics · 2007 · 259 citations

Medicine, Pharmacokinetics, Pharmacology +15