Targeted BCL2 inhibition effectively inhibits neuroblastoma tumour growth

The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized

Mark F. van Delft, Andrew H. Wei, Kylie D. Mason et al. · Cancer Cell · 2006 · 1.2K citations · Full text

Apoptosis, Immunology, Cell Death +4

BCL-2 Is Phosphorylated and Inactivated by an ASK1/Jun N-Terminal Protein Kinase Pathway Normally Activated at G₂/M

Kazuhito Yamamoto, Hidenori Ichijo, Stanley J. Korsmeyer · Molecular and Cellular Biology · 1999 · 998 citations · Full text

Glycogen Synthase Kinase-3 Regulates Mitochondrial Outer Membrane Permeabilization and Apoptosis by Destabilization of MCL-1

Ulrich Maurer, Céline Charvet, Allan S. Wagman et al. · Molecular Cell · 2006 · 866 citations · Full text

Mitochondrial Function, Biochemistry, Natural Sciences +7

Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737

Victoria Del Gaizo Moore, Jennifer R. Brown, Michael Certo et al. · Journal of Clinical Investigation · 2007 · 591 citations · Full text

YM155, a Novel Small-Molecule Survivin Suppressant, Induces Regression of Established Human Hormone-Refractory Prostate Tumor Xenografts

Takahito Nakahara, Masahiro Takeuchi, Isao Kinoyama et al. · Cancer Research · 2007 · 502 citations

Urology, Induces Regression, Chemoprevention Strategy +14