The Journal of Immunology · 1968 · 19 citations · 0 references
Glomerular DiseaseRenal PathologyImmunologyHumoral ResponsePathologyInnate Immune SystemImmune SystemImmune DysregulationInflammationGlomerulonephritisRenal FunctionIga GlomerulonephritisGenetic DeficiencyLupus NephritisAutoimmunityHumoral ImmunityImmunologic DiseaseImmune-mediated Inflammatory DiseasesRenal PathophysiologyInborn Error Of ImmunitySummary Complement-containing ProgenyComplement SystemImmune Tissue InjuryPathogenesisNephrotoxic Serum NephritisNephritic SyndromeGlomerulopathyMedicineNephrologyKidney Research
Summary Complement-containing progeny from the hybridization of B10.D2-old line females with B10.D2-new line males were used to study the role of the complement system in immune tissue injury. Small differences in the severity of nephrotoxic serum nephritis were found following the injection of nephrotoxic serum which implicate the late acting complement components as intensifiers of tissue injury.