Concepedia

Genetic Polymorphisms of Human <b> <i>Flavin Monooxygenase 3</i> </b> in Sulindac-Mediated Primary Chemoprevention of Familial Adenomatous Polyposis

Irfan M. Hisamuddin, Mohammad Wehbi, Ann Chao, Hadley Wyre, Linda M. Hylind, Francis M. Giardiello, Vincent W. Yang

Clinical Cancer Research · 2004 · 56 citations · 29 references

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Abstract

Polymorphisms in FMO3, particularly at the E158K and E308G loci, may reduce activity in catabolizing sulindac and result in an increased efficacy to prevent polyposis in FAP.

References

29

The Effect of Celecoxib, a Cyclooxygenase-2 Inhibitor, in Familial Adenomatous Polyposis

Gideon Steinbach, Patrick M. Lynch, Robin Phillips et al. · New England Journal of Medicine · 2000 · 2.5K citations · Full text

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A Randomized Trial of Aspirin to Prevent Colorectal Adenomas

John A. Baron, Bernard F. Cole, Robert S. Sandler et al. · New England Journal of Medicine · 2003 · 1.4K citations · Full text

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D Labayle, D Fischer, Philippe Vielh et al. · Gastroenterology · 1991 · 725 citations · Full text

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