Concepedia

Publication | Closed Access

Biomarkers of Response to Akt Inhibitor MK-2206 in Breast Cancer

DOI

157

Citations

49

References

2012

Year

Takafumi Sangai, Argun Akçakanat, Huiqin Chen, Emily Tarco, Yun Wu, Kim‐Anh Do, Todd W. Miller, Carlos L. Arteaga, Gordon B. Mills, Ana M. González-Angulo,
Clinical Cancer Research

Abstract

MK-2206 has antitumor activity alone and in combination with chemotherapy. This activity may be greater in tumors with PTEN loss or PIK3CA mutation, providing a strategy for patient enrichment in clinical trials.

References

YearCitations

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