Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

Zhengui Xia, Martin Dickens, Joël Raingeaud et al. · Science · 1995 · 5.3K citations

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

Darren A.E. Cross, Dario R. Alessi, Philip Cohen et al. · Nature · 1995 · 5.2K citations

Signal Transduction, Molecular Physiology, Biochemistry +10

Mechanism of activation of protein kinase B by insulin and IGF-1.

Dario R. Alessi, Mirjana Andjelković, B. Caudwell et al. · The EMBO Journal · 1996 · 3K citations · Full text

Molecular Physiology, Signal Transduction, Signaling Pathway +9

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα

Dario R. Alessi, Stephen R. James, C. Peter Downes et al. · Current Biology · 1997 · 2.8K citations · Full text

Signal Transduction, Molecular Physiology, Signaling Pathway +11

Serine Phosphorylation of Death Agonist BAD in Response to Survival Factor Results in Binding to 14-3-3 Not BCL-XL

Jiping Zha, Hisashi Harada, Elizabeth Yang et al. · Cell · 1996 · 2.6K citations · Full text

Molecular Pharmacology, Signal Transduction, Signaling Pathway +10