Nature · 2010 · 279 citations · 20 references
MedicineMolecular GeneticsOncologyCarcinogenesisMolecular OncologyTumor ProgressionCancer ProgressionCell-cycle CheckpointsLung CancerMalignant NeoplasmsTumor BiologyTumor StagingLung Disease ProgressionP53 InactivationP53 MutationStage-specific SensitivityTumor Suppressor P53
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Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a
Manuel Serrano, Athena W. Lin, Mila E. McCurrach et al. · Cell · 1997 · 5.1K citations · Full text
Medicine, Cell Biology, Oncology +10
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
Wen Xue, Lars Zender, Cornelius Miething et al. · Nature · 2007 · 2.4K citations
Medicine, Cancer Biology, Oncology +16
Restoration of p53 function leads to tumour regression in vivo
Andrea Ventura, David G. Kirsch, Margaret E. McLaughlin et al. · Nature · 2007 · 1.8K citations