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Overcoming hERG issues for brain-penetrating cathepsin S inhibitors: 2-Cyanopyrimidines. Part 2

Osamu Irie, Takatoshi Kosaka, Masashi Kishida, Junichi Sakaki, Keiichi Masuya, Kazuhide Konishi, Fumiaki Yokokawa, Takeru Ehara, Atsuko Iwasaki, Yuki Iwaki,

Bioorganic & Medicinal Chemistry Letters · 2008 · 24 citations · 23 references

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Inhibition of spinal microglial cathepsin S for the reversal of neuropathic pain

Anna K. Clark, Ping K. Yip, John Grist et al. · Proceedings of the National Academy of Sciences · 2007 · 481 citations · Full text

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Toward a Pharmacophore for Drugs Inducing the Long QT Syndrome:  Insights from a CoMFA Study of HERG K<sup>+</sup> Channel Blockers

Andrea Cavalli, Elisabetta Poluzzi, Fabrizio De Ponti et al. · Journal of Medicinal Chemistry · 2002 · 385 citations · Full text

, , +17

Brain Penetration of the Oral Immunomodulatory Drug FTY720 and Its Phosphorylation in the Central Nervous System during Experimental Autoimmune Encephalomyelitis: Consequences for Mode of Action in Multiple Sclerosis

Carolyn A. Foster, Laurence M. Howard, Alain Schweitzer et al. · Journal of Pharmacology and Experimental Therapeutics · 2007 · 324 citations

, , +17

Cathepsin S activity regulates antigen presentation and immunity.

Richard J. Riese, Richard Mitchell, Jóse A. Villadangos et al. · Journal of Clinical Investigation · 1998 · 319 citations · Full text

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Cathepsin L deficiency as molecular defect of <i>furless:</i> hyperproliferation of keratinocytes and pertubation of hair follicle cycling

Wera Roth, Jan M. Deussing, Vladimir A. Botchkarev et al. · The FASEB Journal · 2000 · 309 citations

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