Fumiaki Yokokawa

Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling

Siew Pheng Lim, Christian G. Noble, Cheah C. Seh et al. · PLoS Pathogens · 2016 · 181 citations · Full text

Life Sciences, Infectious Diseases, Molecular Biology +17

Structure, Synthesis, and Biological Properties of Kalkitoxin, a Novel Neurotoxin from the Marine Cyanobacterium <i>Lyngbya </i><i>m</i><i>ajuscula</i>

Min Wu, Tatsufumi Okino, Lisa Nogle et al. · Journal of the American Chemical Society · 2000 · 131 citations

Life Sciences, Pharmacology, Toxicology +12

Antillatoxin is a marine cyanobacterial toxin that potently activates voltage-gated sodium channels

W. I. Li, Frederick W. Berman, Tatsufumi Okino et al. · Proceedings of the National Academy of Sciences · 2001 · 104 citations · Full text

Life Sciences, Neuroscience, Pharmacology +17

Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design

Fumiaki Yokokawa, Shahul Nilar, Christian G. Noble et al. · Journal of Medicinal Chemistry · 2016 · 97 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

NITD-688, a pan-serotype inhibitor of the dengue virus NS4B protein, shows favorable pharmacokinetics and efficacy in preclinical animal models

Stephanie Moquin, Oliver Simon, Ratna Karuna et al. · Science Translational Medicine · 2021 · 93 citations

Life Sciences, Medicinal Chemistry, Pharmacology +17