Cheah C. Seh

Ligand-Bound Structures of the Dengue Virus Protease Reveal the Active Conformation

Christian G. Noble, Cheah C. Seh, Alexander T. Chao et al. · Journal of Virology · 2011 · 297 citations · Full text

Life Sciences, Biology, Infectious Diseases +17

Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling

Siew Pheng Lim, Christian G. Noble, Cheah C. Seh et al. · PLoS Pathogens · 2016 · 181 citations · Full text

Life Sciences, Infectious Diseases, Molecular Biology +17

NITD-688, a pan-serotype inhibitor of the dengue virus NS4B protein, shows favorable pharmacokinetics and efficacy in preclinical animal models

Stephanie Moquin, Oliver Simon, Ratna Karuna et al. · Science Translational Medicine · 2021 · 93 citations

Life Sciences, Medicinal Chemistry, Pharmacology +17

A Crystal Structure of the Dengue Virus Non-structural Protein 5 (NS5) Polymerase Delineates Interdomain Amino Acid Residues That Enhance Its Thermostability and de Novo Initiation Activities

Siew Pheng Lim, Jolene Hong Kiew Koh, Cheah C. Seh et al. · Journal of Biological Chemistry · 2013 · 88 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

A Conserved Pocket in the Dengue Virus Polymerase Identified through Fragment-based Screening

Christian G. Noble, Siew Pheng Lim, Rishi Arora et al. · Journal of Biological Chemistry · 2016 · 76 citations · Full text

Life Sciences, Microbiology, Molecular Biology +16