Angewandte Chemie International Edition · 2007 · 88 citations · 37 references
PharmacyChemistryMedicinal ChemistryNatural Product BiosynthesisOrganic ChemistrySynthetic Medicinal ChemistryAlkaloid BiosynthesisBiomimetic SynthesisOrganic SynthesisBiomimetic Alkaloid SynthesisBiomimetic OxidationBiosynthetic Intermediates In Alkaloid PathwaysIndole AlkaloidsIndole ChemistryIndole SynthesisPlant Alkaloids
A unique oxidation: The first total synthesis of the prenylated indole alkaloids notoamide C and D was accomplished by using a biomimetic oxidation pathway. Oxidation of the putative biosynthetic precursor 1 was achieved in a one-pot reaction to afford notoamide C, its epimer, and notoamide D (see scheme).
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