Concepedia

p53 mediated death of cells overexpressing MDM2 by an inhibitor of MDM2 interaction with p53

Christine Wasylyk, Roberto Salvi, Manuela Argentini, Christine Dureuil, Isabelle Delumeau, Joseph Abecassis, Laurent Debüssche, Bohdan Wasylyk

Oncogene · 1999 · 113 citations · 75 references

DOI

Concepts

References

75

WAF1, a potential mediator of p53 tumor suppression

Wafik S. El‐Deiry, Takashi Tokino, Victor E. Velculescu et al. · Cell · 1993 · 8.4K citations

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Mdm2 promotes the rapid degradation of p53

Ygal Haupt, Ruth Maya, Anat Kazaz et al. · Nature · 1997 · 4.5K citations

, , +10

Participation of p53 protein in the cellular response to DNA damage.

Michael B. Kastan, Onyinye Onyekwere, D Sidransky et al. · PubMed · 1991 · 3.8K citations

, , +14

Regulation of p53 stability by Mdm2

Michael H.G. Kubbutat, Stephen N. Jones, Karen H. Vousden · Nature · 1997 · 3.3K citations

, , +10

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

Jamil Momand, Gerard P. Zambetti, David C. Olson et al. · Cell · 1992 · 3.1K citations

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