Methotrexate attenuates the Th17/IL-17 levels in peripheral blood mononuclear cells from healthy individuals and RA patients

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

Heon Park, Zhaoxia Li, Xuexian O. Yang et al. · Nature Immunology · 2005 · 4.2K citations · Full text

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IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis

Shigeru Kotake, Nobuyuki Udagawa, Naoyuki Takahashi et al. · Journal of Clinical Investigation · 1999 · 1.7K citations · Full text

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Suppression of Immune Induction of Collagen-Induced Arthritis in IL-17-Deficient Mice

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Life Sciences, Immunology, Pathobiology +16

Treatment with a neutralizing anti‐murine interleukin‐17 antibody after the onset of collagen‐induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion

Erik Lubberts, Marije I. Koenders, Birgitte Oppers‐Walgreen et al. · Arthritis & Rheumatism · 2004 · 703 citations

Medicine, Immunology, Pathobiology +17

Multinational evidence-based recommendations for the use of methotrexate in rheumatic disorders with a focus on rheumatoid arthritis: integrating systematic literature research and expert opinion of a broad international panel of rheumatologists in the 3E Initiative

K. Visser, Wanruchada Katchamart, Estíbaliz Loza et al. · Annals of the Rheumatic Diseases · 2008 · 491 citations · Full text

Medicine, Clinical Sciences, Pharmacotherapy +17