The Role of the Breast Cancer Resistance Protein (ABCG2) in the Distribution of Sorafenib to the Brain

Potent and specific inhibition of the breast cancer resistance protein multidrug transporter in vitro and in mouse intestine by a novel analogue of fumitremorgin C.

Arnold van Loevezijn, Jeany M Lakhai, Martin van der Valk et al. · PubMed · 2002 · 687 citations

Medicine, Medicinal Chemistry, Pharmacology +17

The multidrug-resistant phenotype associated with overexpression of the new ABC half-transporter, MXR (ABCG2)

Thomas Litman, Mariafiorella Brangi, Eric A. Hudson et al. · Journal of Cell Science · 2000 · 534 citations · Full text

Medicine, Oncology, Pharmacology +17

Quantitative Atlas of Membrane Transporter Proteins: Development and Application of a Highly Sensitive Simultaneous LC/MS/MS Method Combined with Novel In-silico Peptide Selection Criteria

Junichi Kamiie, Sumio Ohtsuki, Ryo Iwase et al. · Pharmaceutical Research · 2008 · 479 citations

Life Sciences, Biochemistry, Molecular Biology +12

The Effect of Bcrp1 (Abcg2) on the <i>In vivo</i> Pharmacokinetics and Brain Penetration of Imatinib Mesylate (Gleevec): Implications for the Use of Breast Cancer Resistance Protein and P-Glycoprotein Inhibitors to Enable the Brain Penetration of Imatinib in Patients

Pauline Breedveld, Dick Pluim, Greta Cipriani et al. · Cancer Research · 2005 · 351 citations

Medicine, Pharmacokinetics, Pharmacology +16

Erlotinib (Tarceva, OSI-774) Antagonizes ATP-Binding Cassette Subfamily B Member 1 and ATP-Binding Cassette Subfamily G Member 2–Mediated Drug Resistance

Zhi Shi, Xing-Xiang Peng, In‐Wha Kim et al. · Cancer Research · 2007 · 329 citations

Medicine, Oncology, Pharmacology +16