Concepedia

Brain Distribution Coefficient

The Brain Distribution Coefficient is a quantitative pharmacokinetic metric that represents the ratio of a substance's concentration in brain tissue to its concentration in plasma at steady state, used to assess the extent of blood-brain barrier penetration.

120

Publications

5.1K

Citations

682

Authors

236

Institutions

Publications per year

2017–2026

22

Variants

Brain-to-plasma RatioKp,brain

Parents

Publications

120

Enhanced Oral Delivery of Curcumin from N-trimethyl Chitosan Surface-Modified Solid Lipid Nanoparticles: Pharmacokinetic and Brain Distribution Evaluations

Prakash Ramalingam, Young Tag Ko · Pharmaceutical Research · 2014 · 204 citations

, , +14

The Role of the Breast Cancer Resistance Protein (ABCG2) in the Distribution of Sorafenib to the Brain

Sagar Agarwal, Ramola Sane, John R. Ohlfest et al. · Journal of Pharmacology and Experimental Therapeutics · 2010 · 160 citations · Full text

, , +13

Unbound Brain-to-Plasma Partition Coefficient, Kp,uu,brain—a Game Changing Parameter for CNS Drug Discovery and Development

Irena Loryan, Andreas Reichel, Bo Feng et al. · Pharmaceutical Research · 2022 · 151 citations · Full text

, , +14

Greater Than Age-Related Changes in Brain Diffusion of HIV Patients After 1 Year

Linda Chang, Victoria S.S. Wong, Helanna Nakama et al. · Journal of Neuroimmune Pharmacology · 2008 · 128 citations · Full text

, , +9

Dose-response assessment of tariquidar and elacridar and regional quantification of P-glycoprotein inhibition at the rat blood-brain barrier using (R)-[11C]verapamil PET

Claudia Kuntner, Jens P. Bankstahl, Marion Bankstahl et al. · European Journal of Nuclear Medicine and Molecular Imaging · 2009 · 118 citations · Full text

, , +15

1–5 of 120

Authors

682

  1. MH
    Michael H. Abraham

    University College London, United Kingdom

    4 publications · 225 citations

    4

    h-index

  2. YT
    Young Tag Ko

    Gachon University, South Korea

    3 publications · 325 citations

    3

    h-index

  3. ND
    Natalie D. Eddington

    University of Maryland, Baltimore, United States

    3 publications · 87 citations

    3

    h-index

  4. PR
    Prakash Ramalingam

    Gachon University, South Korea

    3 publications · 325 citations

    3

    h-index

  5. TB
    Torbjörn Bäckström

    Umeå University, Sweden

    2 publications · 143 citations

    2

    h-index

1–5 of 682

Institutions

236

  1. University of Minnesota

    Minneapolis, United States

    5 h-index

    20 publications

    624 citations

  2. Uppsala University

    Uppsala, Sweden

    4 h-index

    13 publications

    480 citations

  3. Gachon University

    Seongnam-si, South Korea

    3 h-index

    6 publications

    650 citations

  4. University of North Texas

    Denton, United States

    3 h-index

    3 publications

    177 citations

  5. China Pharmaceutical University

    Nanjing, China

    3 h-index

    24 publications

    568 citations

  6. Inserm

    Paris, France

    3 h-index

    4 publications

    248 citations

  7. University of Maryland, Baltimore

    Baltimore, United States

    3 h-index

    9 publications

    303 citations

  8. Umeå University

    Umeå, Sweden

    3 h-index

    21 publications

    999 citations

1–8 of 236

Venues

  1. Journal of Pharmaceutical Sciences

    7 publications · 308 citations

    7

    h-index

  2. 5

    h-index

  3. European Journal of Pharmacology

    EJP · 4 publications · 172 citations

    4

    h-index

  4. Journal of Chromatography B

    4 publications · 221 citations

    4

    h-index

  5. Cancer Chemotherapy and Pharmacology

    4 publications · 151 citations

    4

    h-index

1–5