TLR2 and neutrophils potentiate endothelial stress, apoptosis and detachment: implications for superficial erosion

Abstract

These in vitro observations and analyses of human plaques indicate that TLR2 stimulation followed by neutrophil participation may render smooth muscle cell-rich plaques susceptible to superficial erosion and thrombotic complications by inducing ER stress, apoptosis, and favouring detachment of EC.