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Synthesis and SAR of 4-(3-hydroxyphenylamino)pyrrolo[2,1-f][1,2,4]triazine based VEGFR-2 kinase inhibitors

R. M. Borzilleri, Zhen‐Wei Cai, Christopher D. Ellis, Joseph Fargnoli, Aberra Fura, Tracy Gerhardt, Bindu Goyal, John T. Hunt, Steven Mortillo, Ligang Qian,

Bioorganic & Medicinal Chemistry Letters · 2005 · 39 citations · 7 references

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7

Bevacizumab plus Irinotecan, Fluorouracil, and Leucovorin for Metastatic Colorectal Cancer

Herbert I. Hurwitz, Louis Fehrenbacher, William Novotny et al. · New England Journal of Medicine · 2004 · 11K citations · Full text

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A Randomized Trial of Bevacizumab, an Anti–Vascular Endothelial Growth Factor Antibody, for Metastatic Renal Cancer

James Chih‐Hsin Yang, Leah Haworth, Richard M. Sherry et al. · New England Journal of Medicine · 2003 · 2.7K citations · Full text

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Binding sites for vascular endothelial growth factor are localized on endothelial cells in adult rat tissues.

Lyn B. Jakeman, Jane Winer, G L Bennett et al. · Journal of Clinical Investigation · 1992 · 438 citations · Full text

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Binding Mode of the 4-Anilinoquinazoline Class of Protein Kinase Inhibitor:  X-ray Crystallographic Studies of 4-Anilinoquinazolines Bound to Cyclin-Dependent Kinase 2 and p38 Kinase

Lisa M. Shewchuk, Anne M. Hassell, Bruce Wisely et al. · Journal of Medicinal Chemistry · 1999 · 236 citations · Full text

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Crystal structure of the kinase domain of human vascular endothelial growth factor receptor 2: a key enzyme in angiogenesis

Michele McTigue, John Wickersham, Chris Pinko et al. · Structure · 1999 · 203 citations

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